Engine notes · research-use
ColabFold / AF2
Live engine on CandleAI lab hub for natural proteins with evolutionary homologs.
Use when
- You want high-accuracy monomer structure with MSA support
- Sequence length is within free (400 aa) or pilot (≤3×400 aa) limits
- You accept public ColabFold MSA for free-path jobs
Prefer other routes later
- Designed / orphan sequences without homologs → ESMFold-class (roadmap)
- Ligands / DNA-RNA complexes → complex engines (roadmap)
- Binder design libraries → RFdiffusion + MPNN (managed)